Deep tissue molecular sensing in vivo

Dartmouth investigators have worked at the forefront of deep tissue optical tomography for years. Current collaborative efforts involve spectral interrogation of tissue composition and exogenous molecular probe uptake. The institution houses one of the largest collections of optical imaging and tomography equipment available, and associated advanced light-transport software — NIRFAST — used by dozens of research groups around the world. 

Dartmouth near infrared spectral tomography for human breast cancer imaging has been implemented, and methodologies to quantify molecular binding in vivo have been pioneered, and continue to evolve through a network of collaborators to realize accurate molecular immunohistochemistry in vivo. The optical instruments, software, and image analysis strategies for thick tissue imaging are all advanced in this effort.

Photoacoustic and acoustic contrast imaging efforts have pioneered higher resolution imaging to sense tumor tissue function and imaging of biological contrast sending.  This work is advanced through the Functional and Molecular Imaging Laboratory with nanotechnology derived contrast agents.